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Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts
OBJECTIVE: Internal tandem duplication (ITD) mutations of the FLT3 receptor are associated with a high incidence of relapse in acute myeloid leukemia (AML). Expression of the CXCR4 receptor in FLT3-ITD–positive AML is correlated with poor outcome, and inhibition of CXCR4 was shown to sensitize AML b...
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| Vydáno v: | Exp Hematol |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777334/ https://ncbi.nlm.nih.gov/pubmed/20035824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2009.12.003 |
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