Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts

OBJECTIVE: Internal tandem duplication (ITD) mutations of the FLT3 receptor are associated with a high incidence of relapse in acute myeloid leukemia (AML). Expression of the CXCR4 receptor in FLT3-ITD–positive AML is correlated with poor outcome, and inhibition of CXCR4 was shown to sensitize AML b...

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Pubblicato in:Exp Hematol
Autori principali: Jacobia, Angela, Thiemea, Sebastian, Lehmann, Romy, Ugarte, Fernando, Malech, Harry L., Koch, Sina, Thiede, Christian, Müller, Katrin, Bornhäuser, Martin, Ryser, Martin, Brennera, Sebastian
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777334/
https://ncbi.nlm.nih.gov/pubmed/20035824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2009.12.003
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