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Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators

Genetic oscillators, such as circadian clocks, are constantly perturbed by molecular noise arising from the small number of molecules involved in gene regulation. One of the strongest sources of stochasticity is the binary noise that arises from the binding of a regulatory protein to a promoter in t...

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Detalhes bibliográficos
Publicado no:Phys Rev E Stat Nonlin Soft Matter Phys
Main Authors: Karapetyan, Sargis, Buchler, Nicolas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777296/
https://ncbi.nlm.nih.gov/pubmed/26764732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1103/PhysRevE.92.062712
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