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Taurolidine and congeners activate hTRPA1 but not hTRPV1 channels and stimulate CGRP release from mouse tracheal sensory nerves

Taurolidine has long been in clinical use as an antimicrobial irrigation that does not impede wound healing. It can even be administered intravenously (30 g/day) to treat sepsis or to exert newly recognized antineoplastic actions. Only one irritant effect is reported, that is, to temporarily induce...

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發表在:Pharmacol Res Perspect
Main Authors: Kichko, Tatjana I., Pfirrmann, Rolf W., Reeh, Peter W.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777271/
https://ncbi.nlm.nih.gov/pubmed/26977296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.204
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