PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells

Retention of long-term repopulating hematopoietic stem cells (LT-HSCs) in the bone marrow is essential for hematopoiesis and for protection from myelotoxic injury. We report that signaling cascades that are traditionally viewed as coagulation-related also control retention of EPCR(+) LT-HSCs in the...

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Gepubliceerd in:Nat Med
Hoofdauteurs: Gur-Cohen, Shiri, Itkin, Tomer, Chakrabarty, Sagarika, Graf, Claudine, Kollet, Orit, Ludin, Aya, Golan, Karin, Kalinkovich, Alexander, Ledergor, Guy, Wong, Eitan, Niemeyer, Elisabeth, Porat, Ziv, Erez, Ayelet, Sagi, Irit, Esmon, Charles T, Ruf, Wolfram, Lapidot, Tsvee
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776769/
https://ncbi.nlm.nih.gov/pubmed/26457757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3960
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