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Strand-biased cytosine deamination at the replication fork causes cytosine to thymine mutations in Escherichia coli
The rate of cytosine deamination is much higher in single-stranded DNA (ssDNA) than in double-stranded DNA, and copying the resulting uracils causes C to T mutations. To study this phenomenon, the catalytic domain of APOBEC3G (A3G-CTD), an ssDNA-specific cytosine deaminase, was expressed in an Esche...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4776466/ https://ncbi.nlm.nih.gov/pubmed/26839411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522325113 |
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