Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation

Antibodies have a well-established modular architecture wherein the antigen-binding site residing in the antigen-binding fragment (Fab or Fv) is an autonomous and complete unit for antigen recognition. Here, we describe antibodies departing from this paradigm. We developed recombinant antibodies to...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Hattori, Takamitsu, Lai, Darson, Dementieva, Irina S., Montaño, Sherwin P., Kurosawa, Kohei, Zheng, Yupeng, Akin, Louesa R., Świst-Rosowska, Kalina M., Grzybowski, Adrian T., Koide, Akiko, Krajewski, Krzysztof, Strahl, Brian D., Kelleher, Neil L., Ruthenburg, Alexander J., Koide, Shohei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2016
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776465/
https://ncbi.nlm.nih.gov/pubmed/26862167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522691113
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