Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation

Antibodies have a well-established modular architecture wherein the antigen-binding site residing in the antigen-binding fragment (Fab or Fv) is an autonomous and complete unit for antigen recognition. Here, we describe antibodies departing from this paradigm. We developed recombinant antibodies to...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Hattori, Takamitsu, Lai, Darson, Dementieva, Irina S., Montaño, Sherwin P., Kurosawa, Kohei, Zheng, Yupeng, Akin, Louesa R., Świst-Rosowska, Kalina M., Grzybowski, Adrian T., Koide, Akiko, Krajewski, Krzysztof, Strahl, Brian D., Kelleher, Neil L., Ruthenburg, Alexander J., Koide, Shohei
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776465/
https://ncbi.nlm.nih.gov/pubmed/26862167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1522691113
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