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Homodimeric Protein-Polymer Conjugates via the Tetrazine-trans-Cyclooctene Ligation
Tetrazine end-functionalized telechelic polymers were synthesized by controlled radical polymerization (CRP) and employed to generate T4 Lysozyme homodimers. Mutant T4 Lysozyme (V131C), containing a single surface-exposed cysteine, was modified with a protein-reactive trans-cyclooctene (T4L-TCO). Re...
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| Udgivet i: | Macromolecules |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4776326/ https://ncbi.nlm.nih.gov/pubmed/26949271 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.macromol.5b02323 |
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