Homodimeric Protein-Polymer Conjugates via the Tetrazine-trans-Cyclooctene Ligation

Tetrazine end-functionalized telechelic polymers were synthesized by controlled radical polymerization (CRP) and employed to generate T4 Lysozyme homodimers. Mutant T4 Lysozyme (V131C), containing a single surface-exposed cysteine, was modified with a protein-reactive trans-cyclooctene (T4L-TCO). Re...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Macromolecules
Autori principali: Lorenzo, Maltish M., Decker, Caitlin G., Kahveci, Muhammet U., Paluck, Samantha J., Maynard, Heather D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776326/
https://ncbi.nlm.nih.gov/pubmed/26949271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.macromol.5b02323
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi