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Structural Insight into Substrate Selectivity of Erwinia chrysanthemil-Asparaginase

[Image: see text] l-Asparaginases of bacterial origin are a mainstay of acute lymphoblastic leukemia treatment. The mechanism of action of these enzyme drugs is associated with their capacity to deplete the amino acid l-asparagine from the blood. However, clinical use of bacterial l-asparaginases is...

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Bibliografische gegevens
Gepubliceerd in:Biochemistry
Hoofdauteurs: Nguyen, Hien Anh, Su, Ying, Lavie, Arnon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2016
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776285/
https://ncbi.nlm.nih.gov/pubmed/26855287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01351
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