Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancom...

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Detalles Bibliográficos
Publicado en:Antimicrob Agents Chemother
Main Authors: Albayati, Zaineb A. F., Sunkara, Manjula, Schmidt-Malan, Suzannah M., Karau, Melissa J., Morris, Andrew J., Steckelberg, James M., Patel, Robin, Breen, Philip J., Smeltzer, Mark S., Taylor, K. Grant, Merten, Kevyn E., Pierce, William M., Crooks, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776008/
https://ncbi.nlm.nih.gov/pubmed/26666918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01609-15
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