Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone

We examined the pharmacokinetic properties of vancomycin conjugated to a bone-targeting agent (BT) with high affinity for hydroxyapatite after systemic intravenous administration. The results confirm enhanced persistence of BT-vancomycin in plasma and enhanced accumulation in bone relative to vancom...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Albayati, Zaineb A. F., Sunkara, Manjula, Schmidt-Malan, Suzannah M., Karau, Melissa J., Morris, Andrew J., Steckelberg, James M., Patel, Robin, Breen, Philip J., Smeltzer, Mark S., Taylor, K. Grant, Merten, Kevyn E., Pierce, William M., Crooks, Peter A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776008/
https://ncbi.nlm.nih.gov/pubmed/26666918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01609-15
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