Amikacin Pharmacokinetics/Pharmacodynamics in a Novel Hollow-Fiber Mycobacterium abscessus Disease Model

The treatment of pulmonary Mycobacterium abscessus disease is associated with very high failure rates and easily acquired drug resistance. Amikacin is the key drug in treatment regimens, but the optimal doses are unknown. No good preclinical model exists to perform formal pharmacokinetics/pharmacody...

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Библиографические подробности
Опубликовано в: :Antimicrob Agents Chemother
Главные авторы: Ferro, Beatriz E., Srivastava, Shashikant, Deshpande, Devyani, Sherman, Carleton M., Pasipanodya, Jotam G., van Soolingen, Dick, Mouton, Johan W., van Ingen, Jakko, Gumbo, Tawanda
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2016
Предметы:
Experimental Therapeutics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775936/
https://ncbi.nlm.nih.gov/pubmed/26643339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02282-15
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