Amikacin Pharmacokinetics/Pharmacodynamics in a Novel Hollow-Fiber Mycobacterium abscessus Disease Model

The treatment of pulmonary Mycobacterium abscessus disease is associated with very high failure rates and easily acquired drug resistance. Amikacin is the key drug in treatment regimens, but the optimal doses are unknown. No good preclinical model exists to perform formal pharmacokinetics/pharmacody...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Ferro, Beatriz E., Srivastava, Shashikant, Deshpande, Devyani, Sherman, Carleton M., Pasipanodya, Jotam G., van Soolingen, Dick, Mouton, Johan W., van Ingen, Jakko, Gumbo, Tawanda
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775936/
https://ncbi.nlm.nih.gov/pubmed/26643339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02282-15
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