Amikacin Pharmacokinetics/Pharmacodynamics in a Novel Hollow-Fiber Mycobacterium abscessus Disease Model

The treatment of pulmonary Mycobacterium abscessus disease is associated with very high failure rates and easily acquired drug resistance. Amikacin is the key drug in treatment regimens, but the optimal doses are unknown. No good preclinical model exists to perform formal pharmacokinetics/pharmacody...

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Bibliografiska uppgifter
I publikationen:Antimicrob Agents Chemother
Huvudupphovsmän: Ferro, Beatriz E., Srivastava, Shashikant, Deshpande, Devyani, Sherman, Carleton M., Pasipanodya, Jotam G., van Soolingen, Dick, Mouton, Johan W., van Ingen, Jakko, Gumbo, Tawanda
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2016
Ämnen:
Experimental Therapeutics
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775936/
https://ncbi.nlm.nih.gov/pubmed/26643339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02282-15
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