Albumin Enhances Caspofungin Activity against Aspergillus Species by Facilitating Drug Delivery to Germinating Hyphae

The modest in vitro activity of echinocandins against Aspergillus implies that host-related factors augment the action of these antifungal agents in vivo. We found that, in contrast to the other antifungal agents (voriconazole, amphotericin B) tested, caspofungin exhibited a profound increase in act...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Ioannou, Petros, Andrianaki, Aggeliki, Akoumianaki, Tonia, Kyrmizi, Irene, Albert, Nathaniel, Perlin, David, Samonis, George, Kontoyiannis, Dimitrios P., Chamilos, Georgios
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775923/
https://ncbi.nlm.nih.gov/pubmed/26643329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02026-15
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