Corticosteroids block autophagy protein recruitment in Aspergillus fumigatus phagosomes via targeting Dectin-1/syk kinase signaling

Aspergillus fumigatus is the predominant airborne fungal pathogen in immunocompromised patients. Genetic defects in NADPH oxidase (chronic granulomatous disease; CGD) and corticosteroid-induced immunosupression lead to impaired killing of A. fumigatus and unique susceptibility to invasive aspergillo...

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Main Authors: Kyrmizi, Irene, Gresnigt, Mark S., Akoumianaki, Tonia, Samonis, George, Sidiropoulos, Prodromos, Boumpas, Dimitrios, Netea, Mihai G, van de Veerdonk, Frank L, Kontoyiannis, Dimitrios P, Chamilos, Georgios
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3883106/
https://ncbi.nlm.nih.gov/pubmed/23817424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300132
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