Herbacetin is a novel allosteric inhibitor of ornithine decarboxylase with antitumor activity

Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity. In this study, we report the...

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Detaylı Bibliyografya
Yayımlandı:Cancer Res
Asıl Yazarlar: Kim, Dong Joon, Roh, Eunmiri, Lee, Mee-Hyun, Oi, Naomi, Lim, Do Young, Kim, Myoung Ok, Cho, Young-Yeon, Pugliese, Angelo, Shim, Jung-Hyun, Chen, Hanyong, Cho, Eun Jin, Kim, Jong-Eun, Kang, Sun Chul, Paul, Souren, Kang, Hee Eun, Jung, Ji Won, Lee, Sung-Young, Kim, Sung-Hyun, Reddy, Kanamata, Yeom, Young Il, Bode, Ann M, Dong, Zigang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775427/
https://ncbi.nlm.nih.gov/pubmed/26676750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0442
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