CInQ-03, a novel allosteric MEK inhibitor, suppresses cancer growth in vitro and in vivo

The mitogen-activated protein kinase kinase 1 and 2 signaling pathway is a major component of the RAS (Rat sarcoma)/RAF (Radpidly accelerated fibrosarcoma)/MEK (mitogen-activated protein kinase kinase)/ERKs (Extracellular signal-regulated kinases) signaling axis that regulates tumorigenesis and canc...

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Détails bibliographiques
Auteurs principaux: Kim, Dong Joon, Lee, Mee-Hyun, Reddy, Kanamata, Li, Yani, Lim, Do Young, Xie, Hua, Lee, Sung-Young, Yeom, Young Il, Bode, Ann M., Dong, Zigang
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2013
Sujets:
Original Manuscript
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643416/
https://ncbi.nlm.nih.gov/pubmed/23354306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgt015
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