Herbacetin is a novel allosteric inhibitor of ornithine decarboxylase with antitumor activity

Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis that is associated with cell growth and tumor formation. Existing catalytic inhibitors of ODC have lacked efficacy in clinical testing or displayed unacceptable toxicity. In this study, we report the...

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I publikationen:Cancer Res
Huvudupphovsmän: Kim, Dong Joon, Roh, Eunmiri, Lee, Mee-Hyun, Oi, Naomi, Lim, Do Young, Kim, Myoung Ok, Cho, Young-Yeon, Pugliese, Angelo, Shim, Jung-Hyun, Chen, Hanyong, Cho, Eun Jin, Kim, Jong-Eun, Kang, Sun Chul, Paul, Souren, Kang, Hee Eun, Jung, Ji Won, Lee, Sung-Young, Kim, Sung-Hyun, Reddy, Kanamata, Yeom, Young Il, Bode, Ann M, Dong, Zigang
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775427/
https://ncbi.nlm.nih.gov/pubmed/26676750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0442
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