Reduced Endoglin Activity Limits Cardiac Fibrosis and Improves Survival in Heart Failure

BACKGROUND: Heart failure is a major cause of morbidity and mortality worldwide. The ubiquitously expressed cytokine, transforming growth factor beta-1 (TGFβ1), promotes cardiac fibrosis, an important component of progressive heart failure. Membrane-associated endoglin is a co-receptor for TGFβ1 sig...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Kapur, Navin K., Wilson, Szuhuei, Yunis, Adil A., Qiao, Xiaoying, Mackey, Emily, Paruchuri, Vikram, Baker, Corey, Aronovitz, Mark J., Karumanchi, S. Ananth, Letarte, Michelle, Kass, David A., Mendelsohn, Michael E., Karas, Richard H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774533/
https://ncbi.nlm.nih.gov/pubmed/22592898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.080002
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