Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

Glioblastoma multiforme (GBM) is an aggressive malignancy associated with profound host immunosuppression mediated in part by FoxP3 expressing regulatory CD4+ T lymphocytes (Tregs) that down-regulate anti-tumor immunity. In order to assess whether FoxP3 was an independent driver differentially expre...

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Bibliographic Details
Published in:Cancer Immunol Immunother
Main Authors: Sayour, Elias J., McLendon, Pat, McLendon, Roger, De Leon, Gabriel, Reynolds, Renee, Kresak, Jesse, Sampson, John H., Mitchell, Duane A.
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2015
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774199/
https://ncbi.nlm.nih.gov/pubmed/25555571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-014-1651-7
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