Increased proportion of FoxP3+ regulatory T cells in tumor infiltrating lymphocytes is associated with tumor recurrence and reduced survival in patients with glioblastoma

Glioblastoma multiforme (GBM) is an aggressive malignancy associated with profound host immunosuppression mediated in part by FoxP3 expressing regulatory CD4+ T lymphocytes (Tregs) that down-regulate anti-tumor immunity. In order to assess whether FoxP3 was an independent driver differentially expre...

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Библиографические подробности
Опубликовано в: :Cancer Immunol Immunother
Главные авторы: Sayour, Elias J., McLendon, Pat, McLendon, Roger, De Leon, Gabriel, Reynolds, Renee, Kresak, Jesse, Sampson, John H., Mitchell, Duane A.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer Berlin Heidelberg 2015
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4774199/
https://ncbi.nlm.nih.gov/pubmed/25555571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-014-1651-7
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