Genetic association analyses highlight biological pathways underlying mitral valve prolapse

Non-syndromic mitral valve prolapse (MVP) is a common degenerative cardiac valvulopathy of unknown aetiology that predisposes to mitral regurgitation, heart failure and sudden death(1). Previous family and pathophysiological studies suggest a complex pattern of inheritance(2–5). We performed a meta-...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Dina, Christian, Bouatia-Naji, Nabila, Tucker, Nathan, Delling, Francesca N., Toomer, Katelynn, Durst, Ronen, Perrocheau, Maelle, Fernandez-Friera, Leticia, Solis, Jorge, Le Tourneau, Thierry, Chen, Ming-Huei, Probst, Vincent, Bosse, Yohan, Pibarot, Philippe, Zelenika, Diana, Lathrop, Mark, Hercberg, Serge, Roussel, Ronan, Benjamin, Emelia J., Bonnet, Fabrice, Su Hao, LO, Dolmatova, Elena, Simonet, Floriane, Lecointe, Simon, Kyndt, Florence, Redon, Richard, Le Marec, Hervé, Froguel, Philippe, Ellinor, Patrick T., Vasan, Ramachandran S., Bruneval, Patrick, Norris, Russell A., Milan, David J., Slaugenhaupt, Susan A., Levine, Robert A., Schott, Jean-Jacques, Hagege, Albert A., Jeunemaitre, Xavier
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773907/
https://ncbi.nlm.nih.gov/pubmed/26301497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3383
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