Genetic association analyses highlight biological pathways underlying mitral valve prolapse

Non-syndromic mitral valve prolapse (MVP) is a common degenerative cardiac valvulopathy of unknown aetiology that predisposes to mitral regurgitation, heart failure and sudden death(1). Previous family and pathophysiological studies suggest a complex pattern of inheritance(2–5). We performed a meta-...

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Pubblicato in:Nat Genet
Autori principali: Dina, Christian, Bouatia-Naji, Nabila, Tucker, Nathan, Delling, Francesca N., Toomer, Katelynn, Durst, Ronen, Perrocheau, Maelle, Fernandez-Friera, Leticia, Solis, Jorge, Le Tourneau, Thierry, Chen, Ming-Huei, Probst, Vincent, Bosse, Yohan, Pibarot, Philippe, Zelenika, Diana, Lathrop, Mark, Hercberg, Serge, Roussel, Ronan, Benjamin, Emelia J., Bonnet, Fabrice, Su Hao, LO, Dolmatova, Elena, Simonet, Floriane, Lecointe, Simon, Kyndt, Florence, Redon, Richard, Le Marec, Hervé, Froguel, Philippe, Ellinor, Patrick T., Vasan, Ramachandran S., Bruneval, Patrick, Norris, Russell A., Milan, David J., Slaugenhaupt, Susan A., Levine, Robert A., Schott, Jean-Jacques, Hagege, Albert A., Jeunemaitre, Xavier
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773907/
https://ncbi.nlm.nih.gov/pubmed/26301497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3383
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