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Increased generation of Foxp3(+) regulatory T cells by manipulating antigen presentation in the thymus

Regulatory T-cell (Treg) selection in the thymus is essential to prevent autoimmune diseases. Although important rules for Treg selection have been established, there is controversy regarding the degree of self-reactivity displayed by T-cell receptors expressed by Treg cells. In this study we have d...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Lin, Jiqiang, Yang, Lu, Silva, Hernandez Moura, Trzeciak, Alissa, Choi, Yongwon, Schwab, Susan R., Dustin, Michael L., Lafaille, Juan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773449/
https://ncbi.nlm.nih.gov/pubmed/26923114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10562
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