Homology Directed Knockin of Point Mutations in the Zebrafish tardbp and fus Genes in ALS Using the CRISPR/Cas9 System

The methodology for site-directed editing of single nucleotides in the vertebrate genome is of considerable interest for research in biology and medicine. The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 type II (Cas9) system has emerged as a simple...

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Bibliographic Details
Published in:PLoS One
Main Authors: Armstrong, Gary Alan Barclay, Liao, Meijiang, You, Zhipeng, Lissouba, Alexandra, Chen, Brian Edwin, Drapeau, Pierre
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4773037/
https://ncbi.nlm.nih.gov/pubmed/26930076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150188
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