Impaired Inactivation of L-Type Ca(2+) Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K(+) Channel Blocking Drugs

The proarrhythmic effects of new drugs have been assessed by measuring rapidly activating delayed-rectifier K(+) current (I(Kr)) antagonist potency. However, recent data suggest that even drugs thought to be highly specific I(Kr) blockers can be arrhythmogenic via a separate, time-dependent pathway...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kim, Jae Gon, Sung, Dong Jun, Kim, Hyun-ji, Park, Sang Woong, Won, Kyung Jong, Kim, Bokyung, Shin, Ho Chul, Kim, Ki-Suk, Leem, Chae Hun, Zhang, Yin Hua, Cho, Hana, Bae, Young Min
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772914/
https://ncbi.nlm.nih.gov/pubmed/26930604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149198
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