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Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression
BACKGROUND: Novel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models. METHODS: Levels of total and phosphorylated MEK and...
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| Publicado no: | BMC Cancer |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4772351/ https://ncbi.nlm.nih.gov/pubmed/26925841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2199-z |
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