First-In-Human safety and long-term exposure data for AAB-003 (PF-05236812) and biomarkers after intravenous infusions of escalating doses in patients with mild to moderate Alzheimer’s disease

BACKGROUND: In the First-In-Human (FIH), 39-week, randomized, adaptive design study, safety, tolerability, pharmacokinetics and biomarkers were measured in patients with mild-to-moderate Alzheimer’s disease (AD) after infusion of a humanized monoclonal antibody to amyloid β, AAB-003 (NCT01193608; re...

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Publicat a:Alzheimers Res Ther
Autors principals: Delnomdedieu, Marielle, Duvvuri, Sridhar, Li, David Jianjun, Atassi, Nazem, Lu, Ming, Brashear, H. Robert, Liu, Enchi, Ness, Seth, Kupiec, James W.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4772335/
https://ncbi.nlm.nih.gov/pubmed/26925577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-016-0177-y
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