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Assessment of megabase-scale somatic copy number variation using single-cell sequencing
Megabase-scale copy number variants (CNVs) can have profound phenotypic consequences. Germline CNVs of this magnitude are associated with disease and experience negative selection. However, it is unknown whether organismal function requires that every cell maintain a balanced genome. It is possible...
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| Published in: | Genome Res |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Cold Spring Harbor Laboratory Press
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4772019/ https://ncbi.nlm.nih.gov/pubmed/26772196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.198937.115 |
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