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Assessment of megabase-scale somatic copy number variation using single-cell sequencing
Megabase-scale copy number variants (CNVs) can have profound phenotypic consequences. Germline CNVs of this magnitude are associated with disease and experience negative selection. However, it is unknown whether organismal function requires that every cell maintain a balanced genome. It is possible...
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| Veröffentlicht in: | Genome Res |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cold Spring Harbor Laboratory Press
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4772019/ https://ncbi.nlm.nih.gov/pubmed/26772196 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.198937.115 |
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