The BBSome Controls Energy Homeostasis by Mediating the Transport of the Leptin Receptor to the Plasma Membrane

Bardet-Biedl syndrome (BBS) is a highly pleiotropic autosomal recessive disorder associated with a wide range of phenotypes including obesity. However, the underlying mechanism remains unclear. Here, we show that neuronal BBSome is a critical determinant of energy balance through its role in the reg...

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Publicat a:PLoS Genet
Autors principals: Guo, Deng-Fu, Cui, Huxing, Zhang, Qihong, Morgan, Donald A., Thedens, Daniel R., Nishimura, Darryl, Grobe, Justin L., Sheffield, Val C., Rahmouni, Kamal
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771807/
https://ncbi.nlm.nih.gov/pubmed/26926121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005890
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