Heterozygous Mutation in IκBNS Leads to Reduced Levels of Natural IgM Antibodies and Impaired Responses to T-Independent Type 2 Antigens

Mice deficient in central components of classical NF-κB signaling have low levels of circulating natural IgM antibodies and fail to respond to immunization with T-independent type 2 (TI-2) antigens. A plausible explanation for these defects is the severely reduced numbers of B-1 and marginal zone B...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Pedersen, Gabriel K., Ádori, Monika, Stark, Julian M., Khoenkhoen, Sharesta, Arnold, Carrie, Beutler, Bruce, Karlsson Hedestam, Gunilla B.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771772/
https://ncbi.nlm.nih.gov/pubmed/26973645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00065
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