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Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System
The p53 transcription factor is a regulator of key cellular processes including DNA repair, cell cycle arrest, and apoptosis. In this theoretical study, we investigate how the complex circuitry of the p53 network allows for stochastic yet unambiguous cell fate decision-making. The proposed Markov ch...
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| Опубликовано в: : | PLoS Comput Biol |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4771203/ https://ncbi.nlm.nih.gov/pubmed/26928575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004787 |
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