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Efficient microbial production of stylopine using a Pichia pastoris expression system

Stylopine is a protoberberine-type alkaloid that has potential biological activities. Based on the successful microbial production of (S)-reticuline, we attempted to produce stylopine from (S)-reticuline by the reaction of berberine bridge enzyme, cheilanthifoline synthase (CYP719A5), and stylopine...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hori, Kentaro, Okano, Shunsuke, Sato, Fumihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770593/
https://ncbi.nlm.nih.gov/pubmed/26923560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22201
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