Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis

During eukaryotic translation initiation, 43S ribosomal complex scans mRNA leader unless an AUG codon in an appropriate context is found. Establishing the stable codon–anticodon base-pairing traps the ribosome on the initiator codon and triggers structural rearrangements, which lead to P(i) release...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Terenin, Ilya M., Akulich, Kseniya A., Andreev, Dmitry E., Polyanskaya, Sofya A., Shatsky, Ivan N., Dmitriev, Sergey E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770231/
https://ncbi.nlm.nih.gov/pubmed/26717981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1514
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