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Regulation of GTP hydrolysis prior to ribosomal AUG selection during eukaryotic translation initiation

Genetic studies in yeast have shown that the translation initiation factor eIF5 plays an important role in the selection of the AUG start codon. In order to ensure translation fidelity, the hydrolysis of GTP bound to the 40S preinitiation complex (40S·Met-tRNA(i)·eIF2·GTP), promoted by eIF5, must oc...

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Detalhes bibliográficos
Main Authors: Majumdar, Romit, Maitra, Umadas
Formato: Artigo
Idioma:Inglês
Publicado em: 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1276726/
https://ncbi.nlm.nih.gov/pubmed/16222335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600844
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