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Regulation of GTP hydrolysis prior to ribosomal AUG selection during eukaryotic translation initiation
Genetic studies in yeast have shown that the translation initiation factor eIF5 plays an important role in the selection of the AUG start codon. In order to ensure translation fidelity, the hydrolysis of GTP bound to the 40S preinitiation complex (40S·Met-tRNA(i)·eIF2·GTP), promoted by eIF5, must oc...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2005
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1276726/ https://ncbi.nlm.nih.gov/pubmed/16222335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600844 |
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