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The first crystal structures of RNA–PNA duplexes and a PNA-PNA duplex containing mismatches—toward anti-sense therapy against TREDs

PNA is a promising molecule for antisense therapy of trinucleotide repeat disorders. We present the first crystal structures of RNA–PNA duplexes. They contain CUG repeats, relevant to myotonic dystrophy type I, and CAG repeats associated with poly-glutamine diseases. We also report the first PNA–PNA...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Kiliszek, Agnieszka, Banaszak, Katarzyna, Dauter, Zbigniew, Rypniewski, Wojciech
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770230/
https://ncbi.nlm.nih.gov/pubmed/26717983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv1513
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