PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells

PKCθ is essential for the activation of CD4(+) T cells. Upon TCR/CD28 stimulation, PKCθ is phosphorylated and migrates to the immunological synapse, inducing the activation of cellular transcription factors such as NF-κB and kinases as ERK that are critical for HIV-1 replication. We previously demon...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: López-Huertas, María Rosa, Li, Jasmine, Zafar, Anjum, Rodríguez-Mora, Sara, García-Domínguez, Carlota, Mateos, Elena, Alcamí, José, Rao, Sudha, Coiras, Mayte
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770193/
https://ncbi.nlm.nih.gov/pubmed/26973648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00069
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