Effects of prunetin on the proteolytic activity, secretion and gene expression of MMP-3 in vitro and production of MMP-3 in vivo

We investigated whether prunetin affects the proteolytic activity, secretion, and gene expression of matrix metalloproteinase-3 (MMP-3) in primary cultured rabbit articular chondrocytes, as well as in vivo production of MMP-3 in the rat knee joint to evaluate the potential chondroprotective eff ect...

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Publicado en:Korean J Physiol Pharmacol
Autores principales: Nam, Dae Cheol, Kim, Bo Kun, Lee, Hyun Jae, Shin, Hyun-Dae, Lee, Choong Jae, Hwang, Sun-Chul
Formato: Artigo
Lenguaje:Inglês
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770113/
https://ncbi.nlm.nih.gov/pubmed/26937219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2016.20.2.221
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