High-affinity self-reactive human antibodies by design and selection: targeting the integrin ligand binding site.
A strategy for the design and selection of human antibodies that bind receptors is described. We have demonstrated the validity of the approach by producing semi-synthetic human antibodies that bind integrins alpha v beta 3 and alpha IIb beta 3 with high affinity (10(-10) M). The selected antibodies...
में बचाया:
| में प्रकाशित: | Proc Natl Acad Sci U S A |
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| मुख्य लेखकों: | , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
National Academy of Sciences
1993
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47701/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7694276/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.21.10003 |
| टैग: |
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