Inside Out Integrin Activation Mediated by PIEZO1 Signaling in Erythroblasts

The non-selective mechanosensitive ion channel PIEZO1 controls erythrocyte volume homeostasis. Different missense gain-of-function mutations in PIEZO1 gene have been identified that cause Hereditary Xerocytosis (HX), a rare autosomal dominant haemolytic anemia. PIEZO1 expression is not limited to er...

Full beskrivning

Bibliografiska uppgifter

Huvudupphov:	Francesca Aglialoro, Naomi Hofsink, Menno Hofman, Nicole Brandhorst, Emile van den Akker
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Frontiers Media S.A. 2020-07-01
Serie:	Frontiers in Physiology
Ämnen:	PIEZO1 integrins calcium signaling integrin α4β1 erythroblastic island
Länkar:	https://www.frontiersin.org/article/10.3389/fphys.2020.00958/full
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!