Mutation of lysine 396 of the fusion protein reduces its binding affinity with integrin αVβ1 and leads to attenuation of avian metapneumovirus subtype B

ABSTRACT Avian metapneumovirus subtype B (aMPV/B) infections significantly affect the global poultry industry. However, the virulence determinants and attenuation mechanism remain unknown. Here, a series of chimeric and mutant viruses was constructed, and their pathogenicity was evaluated in a speci...

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主要な著者:	Lingzhai Meng, Yuntong Chen, Mengmeng Yu, Yongzhen Liu, Suyan Wang, Xiaoxiao Xue, Wenrui Fan, Ying Wang, Tao Zhang, Peidong Guo, Ru Guo, Mingxue Hu, Xiaole Qi, Yanping Zhang, Yulu Duan, Hongyu Cui, Yulong Gao
フォーマット:	Artigo
言語:	Inglês
出版事項:	American Society for Microbiology 2026-05-01
シリーズ:	mBio
主題:	avian metapneumovirus subtype B virulence attenuation mechanism αVβ1 integrin binding
オンライン･アクセス:	https://journals.asm.org/doi/10.1128/mbio.00424-26
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