Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice

Induction of the iron regulatory hormone hepcidin contributes to the anemia of inflammation. Bone morphogenetic protein 6 (BMP6) signaling is a central regulator of hepcidin expression in the liver. Recently, the TGF-β/BMP superfamily member activin B was implicated in hepcidin induction by inflamma...

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Veröffentlicht in:Endocrinology
Hauptverfasser: Canali, Susanna, Core, Amanda B., Zumbrennen-Bullough, Kimberly B., Merkulova, Maria, Wang, Chia-Yu, Schneyer, Alan L., Pietrangelo, Antonello, Babitt, Jodie L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Endocrine Society 2016
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769363/
https://ncbi.nlm.nih.gov/pubmed/26735394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2015-1747
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