Endogenous Toll-Like Receptor 9 Regulates AKI by Promoting Regulatory T Cell Recruitment

Toll-like receptor 9 (TLR9) enhances proinflammatory responses, but whether it can act in a regulatory capacity remains to be established. In experimental murine AKI induced by cisplatin, Tlr9(−/−) mice developed enhanced renal injury and exhibited fewer intrarenal regulatory T cells (Tregs) compare...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Alikhan, Maliha A., Summers, Shaun A., Gan, Poh Y., Chan, Amy J., Khouri, Mary B., Ooi, Joshua D., Ghali, Joanna R., Odobasic, Dragana, Hickey, Michael J., Kitching, A. Richard, Holdsworth, Stephen R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2016
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769185/
https://ncbi.nlm.nih.gov/pubmed/26116356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2014090927
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