Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study

BACKGROUND: Aminoglycoside O-phosphotransferases make up a large class of bacterial enzymes that is widely distributed among pathogens and confer a high resistance to several clinically used aminoglycoside antibiotics. Aminoglycoside 2″-phosphotransferase IVa, APH(2″)-IVa, is an important member of...

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Veröffentlicht in:Biochim Biophys Acta
Hauptverfasser: Kaplan, Elise, Guichou, Jean-François, Chaloin, Laurent, Kunzelmann, Simone, Leban, Nadia, Serpersu, Engin H., Lionne, Corinne
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Pub. Co 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769084/
https://ncbi.nlm.nih.gov/pubmed/26802312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.01.016
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