PRMT5-Mediated Methylation of NF-κB p65 at Arg(174) Is Required for Endothelial CXCL11 Gene Induction in Response to TNF-α and IFN-γ Costimulation

Inflammatory agonists differentially activate gene expression of the chemokine family of proteins in endothelial cells (EC). TNF is a weak inducer of the chemokine CXCL11, while TNF and IFN-γ costimulation results in potent CXCL11 induction. The molecular mechanisms underlying TNF plus IFN-γ-mediate...

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Foilsithe in:PLoS One
Main Authors: Harris, Daniel P., Chandrasekharan, Unnikrishnan M., Bandyopadhyay, Smarajit, Willard, Belinda, DiCorleto, Paul E.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2016
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768879/
https://ncbi.nlm.nih.gov/pubmed/26901772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0148905
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