Tumor Necrosis Factor (TNF)-α Induction of CXCL10 in Endothelial Cells Requires Protein Arginine Methyltransferase 5 (PRMT5)-mediated Nuclear Factor (NF)-κB p65 Methylation

The chemokine CXCL10/IP-10 facilitates recruitment of Th1-type leukocytes to inflammatory sites. In this study, we show that the arginine methyltransferase PRMT5 is critical for CXCL10 transcription in TNF-α-activated human endothelial cells (EC). We found that depletion of PRMT5 results in signific...

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Bibliographic Details
Main Authors: Harris, Daniel P., Bandyopadhyay, Smarajit, Maxwell, Tyler J., Willard, Belinda, DiCorleto, Paul E.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140890/
https://ncbi.nlm.nih.gov/pubmed/24753255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.547349
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