HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P(1) to limit vascular inflammation

The sphingosine 1-phosphate receptor 1 (S1P(1)) is abundant in endothelial cells, where it regulates vascular development and microvascular barrier function. In investigating the role of endothelial cell S1P(1) in adult mice, we found that the endothelial S1P(1) signal was enhanced in regions of the...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Sci Signal
Huvudupphovsmän: Galvani, Sylvain, Sanson, Marie, Blaho, Victoria A., Swendeman, Steven L., Obinata, Hideru, Conger, Heather, Dahlbäck, Björn, Kono, Mari, Proia, Richard L., Smith, Jonathan D., Hla, Timothy
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4768813/
https://ncbi.nlm.nih.gov/pubmed/26268607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa2581
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk