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HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P(1) to limit vascular inflammation
The sphingosine 1-phosphate receptor 1 (S1P(1)) is abundant in endothelial cells, where it regulates vascular development and microvascular barrier function. In investigating the role of endothelial cell S1P(1) in adult mice, we found that the endothelial S1P(1) signal was enhanced in regions of the...
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| Publié dans: | Sci Signal |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4768813/ https://ncbi.nlm.nih.gov/pubmed/26268607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aaa2581 |
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